UJI EFEKTIVITAS ANTIINFLAMASI EKSTRAK KULIT BATANG JAMBU METE (Anacordium occidentale) PADA HEWAN UJI MENCIT (Mus Musculus)

Abstract

This study aims to determine the anti-inflammatory effect of cashew nut bark extract (Anacardium occidentale). The cashew nut bark was extracted using the reflux method to obtain a thick extract. Cashew nut bark extracted was made at a concentration of 2% w/v, 4% w/v and 8% w/v. Male mice were induced with albumin and then given cashew nut bark extract 2% w/v, 4% w/v and 8% w/v with positive control sodium diclofenac and 1% w/v Na.CMC as negative control. The research data showed that cashew nut bark extract 8% w/v had the most effective anti-inflammatory effect than 2% w/v and 4% w/v cashew nut bark extract, but the anti-inflammatory effect was still lower than diclofenac sodium

Penelitian ini bertujuan untuk mengetahui efek antiinflamasi dari kulit batang jambu mete (Anacordium occidentale). Kulit batang jambu mete di ekstraksi dengan menggunakan metode refluks hingga diperoleh ekstrak kental. Ekstrak kulit batang jambu mete dibuat konsentrasi 2% b/v, 4% b/v dan  8% b/v.  Mencit jantan diinduksi dengan albumin lalu diberi ekstrak kulit batang jambu mete 2% b/v, 4% b/v dan 8% b/v dengan kontrol positif Natrium Diklofenak dan Na.CMC 1% b/v sebagai kontrol negatif. Data hasil penelitian efek antiinflamasi mencit dianalisis dengan menggunakan ANOVA. Hasil penelitian penelitian menunjukkan ekstrak kulit batang jambu mete 8% b/v memiliki efek antiinflamasi yang paling efektif daripada ekstrak kulit batang jambu mete 2 % b/v dan 4 % b/v namun efek antiantiinflamasi nya masih lebih rendah daripada Natrium Diklofenak.