Efek Ekstrak Daun Ceremai (Phyllanthus acidus (L.) Skeels) Sebagai Antidiabetes Terhadap Tikus Putih Yang Di Induksi Aloksan

Abstract

Increased levels of glucose in blood plasma beyond normal limits (hyperglycemia) is one of the basics for diagnosing Diabetes Mellitus. Diabetes Mellitus (DM) is a disease caused by high blood sugar levels due to impaired insulin secretion. The purpose of this study was to determine the effect of Phyllanthus leaf extract as antidiabetic against alloxan-induced white rats and to determine the optimal dose as antidiabetic against white rats. The test material used was Phyllanthus Leaf which was extracted by Maceration with Ethyl Acetate as solvent. This study used 15 white rats which were divided into 5 treatment groups, each group consisted of 3 white rats, namely group I (Na.CMC), group II (extract dose 100 mg/KgBB), group III (extract dose 200 mg /KgBW), group IV (extract dose of 400 mg/KgBW), and group V (Glibenclamide). The results showed that the administration of Phyllanthus Leaf extract could reduce the blood glucose levels of White Rats with an average value where the extract dose of 100 mg/kgBW was 54.71%, the extract dose of 200 mg/kgBW was 61.14% and the extract dose was 400 mg/kg. kgBB by 74.53%. Phyllanthus Leaf Extract at a dose of 400 mg/kgBW had a non-significant effect on the positive control of Glibenclamide. However, the average percentage of decrease in blood glucose levels that was greatest was in the positive control group (Glibenclamide) which was 81.47%.