Uji Efek Analgetik Ekstrak Etanol Kulit Batang Kayu Manis (Cinnamomum burmanii) Terhadap Hewan Uji Mencit (Mus musculus)

Abstract

Cinnamon bark (Cinnamomum burmanii) contains limonene, tannins, coumarins and has been widely used for its diaphoretic, antirheumatic and allagetic properties. This study aims to determine the analgesic effect of ethanol extract of cinnamon bark on mice (Mus musculus). In this study, 15 mice were used which were divided into 5 groups. Group I as negative control, group II as positive control were given mefenamic acid suspension, groups III, IV and V were given cinnamon bark extract with 1%, 2% and 3% respectively. Before being given treatment, all groups were given 1% acetic acid induction intraperitoneally. After 30 minutes, the treatment was given orally and the amount of stretching was observed at five minute intervals for one hour. The results showed that concentrations of 1%, 2% and 3% could provide an analgesic effect and the most effective concentration was 3% with a percentage of 38,32%.